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Santa Cruz Biotechnology
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MedKoo Inc
cx-4945 (5-(3-chlorophenylamino)benzo[c][2,6]naphthyridine-8-carboxylic acid ![]() Cx 4945 (5 (3 Chlorophenylamino)benzo[C][2,6]Naphthyridine 8 Carboxylic Acid, supplied by MedKoo Inc, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more https://www.bioz.com/product/cx+4945/pm35755813-57-31-52?v=MedKoo+Inc Average 90 stars, based on 1 article reviews
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SYNkinase
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Advanced ChemBlocks Inc
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Adooq Bioscience LLC
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Senhwa Biosciences
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CEM Corporation
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ApexBio
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Merck KGaA
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AbMole Bioscience
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Image Search Results
Journal: The American journal of pathology
Article Title: CK2α/CSNK2A1 Phosphorylates SIRT6 and Is Involved in the Progression of Breast Carcinoma and Predicts Shorter Survival of Diagnosed Patients.
doi: 10.1016/j.ajpath.2016.08.007
Figure Lengend Snippet: Figure 2 Inhibition of CSNK2A1 decreased the proliferation and invasiveness of breast cancer cells. A and B: Treatment with the CSNK2 inhibitors, CX4945 (A) and emodin (B), significantly inhibited the growth of both MCF7 and T47D cells in a dose- and time-dependent manner. C: The knockdown of CSNK2A1 inhibited the proliferation of both MCF7 and T47D cells as indicated by MTT and colony-forming assays. D: The sub-G1 and G0/G1 population increased with the knockdown of CSNK2A1 in flow cytometric cell cycle analysis. E and F: The knockdown of CSNK2A1 significantly reduced cell migration (E) and invasion (F) in both MCF7 and T47D cell lines. *P < 0.05, **P < 0.01, and ***P < 0.001. CSNK2A1, casein kinase 2 a1.
Article Snippet: Two CSNK2 inhibitors,
Techniques: Inhibition, Knockdown, Cell Cycle Assay, Migration